Although these other toxins are clinically similar, this topic specifically discusses toxicity from digoxin. decontamination and enhanced elimination respectively) Antidotes have a surprisingly minor role in the management of most poisonings, their use is restricted to. They do not primarily affect the systemic absorption or removal of toxic agents from the body (i.e. Digibind is a sterile freeze-dried powder of antigen binding fragments (Fab) obtained from antidigoxin antibodies raised in sheep. Antidotes are agents that counteract the effects of a toxic agent on the body. Digibind Injection belongs to a group of medicines called the antigen binding fragments. In addition to pharmaceuticals, toxicity can also occur from exposure to a number of plants and animals that contain cardioactive corticosteroids, including dogbane, foxglove, lily of the valley, oleander, yellow oleander, red quill, and the Bufo species toad. Digibind Injection is an antidote used to treat life-threatening digoxin or digitoxin overdose. Mechanism of Action: Digoxin immune Fab are antibodies that bind to digoxin. Serum digoxin concentration is usually greater than the therapeutic range of 0.5 to 0.9 nanograms/mL, but may not be elevated. Trade Name: Digibind ® Drug Class: Digoxin antidote. In therapeutic doses, digoxin increases cardiac contractility and controls the heart rate.ĭigoxin toxicity is a clinical diagnosis that relies in part on ECG findings such as signs of increased automaticity and atrioventricular node blockade (premature ventricular contractions, slowed ventricular response). An account of the foxglove, and some of its medical uses: with practical remarks on dropsy and other diseases. It is indicated for the treatment of mild to moderate heart failure. Digoxin is the most commonly prescribed cardioactive corticosteroid in the US.
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